The Role of Intestinal Microbiote
in Neuromuscular Diseases in Paralized
Dogs
Gheorghe
GIURGIU1*, Manole COJOCARU2
1Deniplant-Aide
Sante Medical Center, Biomedicine, Bucharest, 012371, Romania
2Titu Maiorescu
University, Faculty of Medicine, Bucharest, 031593, Romania
*
Corresponding author e-mail: deniplant@gmail.com
Abstract
In order to be able to move, animals like man need the nervous and muscular
system to function optimally. The brain,
spine, nerves and muscles must work together.
If there is a disturbance, the messages will not reach the destination
and the animal will not be able to move. Depending on the location and extent
of the neurological lesions, the dog may paralyze in whole or in part.
Post-traumatic paralysis is a complex condition that requires proper treatment
and thorough investigations to establish an accurate diagnosis. There are
several conditions that can cause paralysis in the dog. The interaction between
the health of the microbiome and that of the brain as well as the way it
communicates immune and neuronal cells has been studied. Intestinal cells affect the cells of the
central nervous system in the brain. The intestinal-brain axis may influence
different neurological disorders and it is possible that dysbiosis in the
intestinal tract may lead to disturbance of the transmission of nerve controls
on the neuromuscular plate. By-products of microorganisms in the intestine,
which appear as a result of tryptophan processing in the diet, can limit the
level of inflammation in the brain by the influence they have on microglial
cells. The current research focuses on the influence that the gut microbiota
has on microglial cells and astrocytes that play an important role in the
health of the central nervous system. To reach these observations, the authors
examined how intestinal microbiota and diet influence amelioration of paralysis
in dogs. In conclusion, the link between the health of the microbiome and the
health of the brain, shows how the microorganisms in the intestine influence
the evolution of paralysis.
Keywords: microbiome,
intestinal dysbiosis, neuroimmunomodulation, paralysis, dog.
DOI https://doi.org/10.56082/annalsarscibio.2020.1.88
