New
insights into Skin Microbiota in Acne Pathophysiology
Gheorghe
GIURGIU1 , Manole COJOCARU2
1 Deniplant-Aide Sante Medical Center, Biomedicine,
Bucharest, 012371, Romania
2 Titu Maiorescu University, Faculty of Medicine,
Bucharest, 031593, Romania
Corresponding author e-mail: deniplant@gmail.com
Abstract
The role of skin
microbiota in acne remains to be fully elucidated. The emotions of stress
(e.g., depression and anxiety), for instance, have been hypothesized to
aggravate acne by altering the gut microbiota and increasing intestinal
permeability, potentially contributing to skin inflammation. It is increasingly
believed that the interaction between skin microbes and host immunity plays an
important role in this disease, with perturbed microbial composition and
activity found in acne patients. Acne also has close connections with the
gastrointestinal tract, and many argue that the gut microbiota could be
involved in the pathogenic process of acne. Diet also shapes the gut
microbiota. Emerging data suggest that dietary factors (i.e., the Western diet)
may influence acne development. Growing evidence indicates that probiotics
modify the pathophysiologic factors that contribute to acne, potentially
improving patient compliance. Probiotics also have immunomodulatory properties
on keratinocytes and epithelial cells. Taken together, the findings suggest
that the microbiota plays an important role in acne pathogenesis and can be
modulated for clinical improvement, but efforts should be made to identify the
exact mechanisms and therapeutic effects of oral/topical probiotics in acne.
This presentation concentrates on the skin and gut microbes in acne, the role
that the gut brain skin axis plays in the immunobiology of acne, and newly
emerging microbiomebased therapies that can be applied to treat acne. With the
help of Deniplant brand natural remedies, the authors have developed several
products for acne that act as immunomodulators of the human microbiome.
Keywords: acne, microbiota, skin, gut, brain, therapeutic implications
DOI https://doi.org/10.56082/annalsarscibio.2021.1.12