A Review on Biomimetic Hydroxyapatites for Biomedical
Applications
Alexandra AVRAM 1,
Gheorghe TOMOAIA2, 3, Aurora MOCANU 1,
Maria TOMOAIA-COTISEL* 1, 3
1 Babes-Bolyai
University of Cluj-Napoca, Faculty of Chemistry and Chemical Engineering,
Research Centre of Physical Chemistry, 11 Arany Janos Str., RO-400028, Cluj-Napoca, Romania
2 Iuliu
Hatieganu University of Medicine and Pharmacy,
Department of Orthopedic Surgery, General Traian Mosoiu Str., RO-400132, Cluj-Napoca, Romania
3
Academy
of Romanian Scientists, 54 Splaiul Independentei, RO-050094, Bucharest, Romania
* Corresponding author e-mail: mcotisel@gmail.com
mcotisel.chem.ubbcluj.ro@gmail.com
Abstract
This
review provides an overview of characteristics on nano hydroxyapatite, HAP,
with an emphasis on the improvement of its properties for biomedical
applications, on the basis of our original research in the context of the state
of the art. We consider the biological effects inspired by the role of HAP and
physiological essential elements in the metabolism, development and
regeneration of bone. The employment of multiple strategies to tackle the
multi-substitution in the HAP lattice, resulting in multi-substituted
hydroxyapatites, ms-HAPs, is likely to be accompanied
by improvements of HAP properties as biomimetic hydroxyapatites for bone
substitutes and dental cements for biomedical applications. The obtained
nanostructured innovative biomaterials are briefly characterized by various
physical and chemical methods. Due to the excellent capacity of HAP and ms-HAPs to adsorb various ions and biomolecules, like
antimicrobial agents, they are major carriers for infection therapy. Also, we demonstrated that HAP is very
efficient for the heavy metal removal from wastewater, such as industrial and
mine water.
Keywords: hydroxyapatite, substituted hydroxyapatites,
XRD, thermal treatment, morphological characterization.
DOI https://doi.org/10.56082/annalsarscibio.2020.2.106
